Okay this comes from 1up taking a look at the back of the re5 box.

“Looks like their might be a little more to Resident Evil 5 than meets the eye. Specifically, offline multiplayer featuring up to 16 players.
While having a close look at the Xbox 360 Resident Evil 5 boxart, the eagle-eyed folks over at D-Pad (via Videogaming247) noticed the phrase “system link 2-16.” When contacted by Videogaming247 for comment, all Capcom would say was, “I can confirmed that our box art isn’t lying. That’s all though.”

So if you’re willing to lug a whole lot of Xbox 360’s over to a friend’s house, it looks like Resident Evil 5 has serious offline multiplayer potential. As to what exactly the multiplayer modes could entail, we’ll leave the speculation up to you.”

Sounds sick to me, hopefully just a whole mess of people fighting a flood of zombies. That would be fricken awesome.